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Nrf2 activation stimulates the body to produce more Glutathione - the body's most powerful anti-oxidant to reduce oxidative stress and prevent free radical damage


With a traditional anti-oxidant supplement one anti-oxidant neutralises one free radical.

With Protandim, Nrf2 activation stimulates the production of far more anti-oxidants, effectively massively amplifying the antioxidant effect on a comparative per mg basis.

World Champion boxer Manny Pacquiao with Protandim. Reducing oxidative stress increases athletic performance potential.

LifeVantage Company

Dr. Joe McCord, who alongside his supervisor, discovered Superoxide Dismutase (SOD) developed the flagship Nrf2 activator known as Protandim.

U.S. retail sales of Protandim boomed after appearing on national TV, but it was quickly lost again in the glut of nutraceutical products on the health store and pharmacy shelves.  Retail store employees didn’t have the knowledge or understanding about why Protandim stands head and shoulders above the rest, or the motivation to sell it ahead of other products.

LifeVantage® decided to remove Protandim from retail shelves and in 2009 implemented a network marketing business method better suited to Protandim distribution by people who had benefitted from it,  so they had the passion to share their's and Protandim's story.

It was a new beginning for LifeVantage that has resulted in a healthy Nasdaq share price, an 87% customer retention figure that is based on real health improvements and from people fully understanding what makes Protandim different.

LifeVantage is a burgeoning science-based nutraceutical company dedicated to helping people achieve healthy living through a combination of scientifically validated products and an attractive business opportunity.

If the business opportunity sounds interesting, then contact Roger, or simply sign up via the link below. There is no pressure to do any more than you are happy with but increased efforts brings increased rewards. It's up to you!!

Sign up here ...


Comprised of natural plant ingredients, Protandim is a patented, science-based formula that has been researched, tested and validated by renowned universities and institutions. Science research and literature demonstrate the importance of cellular health. Protandim combines traditional ingredients that have been used to help support cellular health and general well being.

Natural and Potent

Protandim, protected by six U.S. patents, is made of five potent botanicals. Learn more about each ingredient and their essential role in the science of Protandim.

Turmeric Extract (Rhizome)

Turmeric is a rhizomatous herbaceuos perennial plant of the ginger family, Zingiberaceae. Native to tropical South Asia, it needs temperatues between 20C and 30C, as well as a considerable amount of annual rainfall to thrive. Traditionally, it has been used to support gall bladder function.

Milk Thistle Extract (Seed)

Milk thistle is a tall, flowering plant with spiny stems and toothed, thorny leaves. Native to the Mediterranean, this plant can now be found throughout the world. It has been used for hundreds of years as a liver protectant and to support liver function.

Green Tea Extract (Leaf)

Green tea comes form a tea plant native to Asia called Camellia Sinensis, the same plant that is the source of black tea. What makes green tea different, and green, is not the plant used to make the tea, but how it is processed. This much studied extract, produced from Camellia Sinensis leaves in China, is used as a source of antioxidants for the preservation of good health.

Black Pepper

Black pepper comes from the berries of the pepper plant. Black pepper, green pepper and white peppercorns are actually the same fruit (Piper nigrum); the difference in their color is a reflection of varying stages of development and processing methods. Traditionally used to improve digestion.

Bacopa Extract (Aerial Part)

Bacopa extract is taken from the succulent leaves of a small creeping plant commonly found growing throughout damp and marshy wetlands of India. This herb, with its small white flowers, is often mistaken for a water lily, although the two are unrelated. Bacopa has been traditionally used for good health.


It is the relative proportions of the ingredients that has been established through meticulous research that makes Protandim as a blended product much greater than the sum of all the parts individually. The activity of Protandim cannot be easily or readily replicated simply by taking all the ingredients together in random amounts or by trying your own recipe!

Dr Joe McCord: Protandim Head Scientist

Dr. Joe McCord, the scientist behind Protandim, devoted his life to the role of free radicals and the problems associated with ageing. One of his discoveries, super oxide dismutase (SOD), is so significant it has been mentioned in over 50,000 peer-reviewed publications.

For his work, Dr. McCord was awarded the Elliott Cresson Medal from The Franklin Institute, presented to distinguished inventors and scientists, putting Dr. McCord in the same company as Pierre and Marie Curie, Alexander Graham Bell, Orville Wright and Henry Ford.

Oxidative Stress

Oxidative stress is the medical term for inflammation and damage caused by free radicals which are a by-product of the chemical reactions that go on in every cell in our body many millions of times per second. When we are young and healthy our body produces anti-oxidants to neutralise the free radicals (now called Reactive Oxygen Species = ROS) that cause this damage. The most powerful anti-oxidant produced in the body naturally is called Super Oxide Dismutase (SOD) which is also known as Glutathione. The gene that controls production of SOD is called Nrf2. After puberty when we finish growing and from our 20s onwards, production of SOD reduces and as we get older this free radical damage accumulates and becomes more clinically significant. Lifestyle - including diet, alcohol consumption, little sleep, stress, pollution etc can all increase ROS production. Diseases which result from this chronic inflammation become more common and worse with age. These inflammatory diseases include arthritis, cancers and increase the likelihood of strokes and heart disease etc. The diagram below is a summary of just some of the many conditions. Most if not all disease has oxidative stress somewhere in the background.


Up until now the primary method of dealing with ROS and oxidative stress was to supplement with anti-oxidants. When first discovered, people thought they were the answer to ageing and immortal life but it hasn't worked out that way! Firstly, some ROS also have a signalling action so a more selective approach is needed to maintain these at least until they have done their signalling activity whilst neutralising others as soon as possible after production. Secondly there is a tendency when supporting a process within the body to get an initial boost of action followed by a return to the previous situation as the body down-regulates it's own activity and relies on the supplement.

Protandim bypasses these problems by activating the Nrf2 gene to naturally increase production of SOD and then let the body choose what needs neutralising and when. There are certain inflammatory markers in the body that are used to assess our balance of oxidative stress versus anti-oxidant levels called TBARS which naturally tend to increase with age. The following graphs were obtained in trials using Protandim.

before Protandim.gif

Following supplementation with Protandim for just one month the following graph was obtained ...

Tbar Chart.gif

TBAR levels generally returned to youthful levels and were maintained there, indicating that SOD levels were coping better with the usual age-related levels of ROS so thereby helping reduce and prevent diseases rooted in inflammation.

Whilst, Protandim can help the body produce more SOD to neutralise ROS it still relies on the body to be able to respond in individual cases. The ability for the body to respond will be determined by nutrition and lifestyle etc. A better response is likely to be attained by improving these rather than relying on Protandim as a strategy to support continued unhealthy living!! Having said that, if lifestyle is generally good and nutrition is improved with Quinton then Protandim may have the significant benefits for you that some people have reported for themselves.